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Study published in Nature shows the Mirvie RNA platform can effectively identify 75% of pregnancies who later develop preeclampsia, months in advance.
Study analyzed RNA in 2,539 blood samples from 1,840 women in the United States, Europe and Africa.
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Rasmussen, et al. RNA profiles reveal signatures of future health and disease in pregnancy. Nature. 2022.
FINDINGS:
  • RNA messages change over time as pregnancy progresses, revealing the biology of fetal development and other dynamic processes.
  • RNA messages can be used to establish pregnancy dating, with an accuracy comparable to second-trimester ultrasound and superior to third-trimester ultrasound.
  • The Mirvie RNA Platform can provide a simple, objective, and actionable assessment of preeclampsia risk.
CLINICAL SIGNIFICANCE:
The Mirvie RNA Platform provides an objective assessment of risk independent of a woman’s demographics and clinical risk factors (e.g. race, age).
  • Superior to prediction based on clinical factors.¹
  • Clinical risk factors can be complex and subjective, difficult to apply consistently to guide care.2,3
  • For every 100 patients who have at least 1 high risk factor for PE, 54 do not receive a recommendation to take aspirin. For those with 2 or more moderate risk factors, only 3.6-6.7% receive a recommendation to take aspirin.³
“Our approach opens new therapeutic windows to effectively decrease maternal and neonatal morbidity and mortality.”  - Nature Study Authors: Rasmussen, et al. RNA profiles reveal signatures of future health and disease in pregnancy. Nature. 2022.
1. Tan, et al. Screening for pre-eclampsia by maternal factors and biomarkers at 11-13 weeks' gestation. Ultrasound Obstet Gynecol. 2018  2. USPSTF, et al. Aspirin Use to Prevent Preeclampsia and Related Morbidity and Mortality: US Preventive Services Task Force Recommendation Statement. JAMA. 2021  3. Krishnamurti, et al. Use of a Smartphone App to Explore Potential Underuse of Prophylactic Aspirin for Preeclampsia. JAMA Netw Open. 2021
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